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I had a single cylinder misfire code (#6) so i decided to start with new plugs hoping it was that simple. Changed all the plugs, putting in Bosch Platinum 4's, now the car doesn't even start. I've rechecked to make sure each of the coils was seated properly and they were. So now I'm here for your thoughts. I'm guessing it's on to replacing the coils at this point. Also, in case you're wondering the engine codes I was getting were P0300, P0306, and P1314.
Well first thing I would check is that Coils 5 and 6 are connected correctly (common mistake after plug change). They should be like this. Note 6 is different orientation to the others and normally has a yellow tape on the cable.
If they're ok, then check out Aholbro1's excellent collection of no start issues and solutions before you go replacing coils.